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Evaluation of the zinc-fingers and homeoboxes 3 as a potential biomarker for prognosis prediction in lung adenocarcinoma

Abstract: Lung cancer is one of the leading malignant cancers in the world with high incidence and mortality and lung adenocarcinoma (LUAD) is its major histologic subtype.…

Date: 2025-12-17

Admission monocyte-to-albumin ratio predicts 3-month functional outcomes after acute ischemic stroke: a retrospective cohort study

Abstract: The monocyte-to-albumin ratio (MAR) integrates systemic inflammation and nutritional status derived from routine laboratory data. We assessed whether the admission MAR…

Date: 2025-12-17

Association between family support and 6-months functional recovery in acute ischemic stroke patients: a prospective cohort study

Abstract: Stroke is a leading cause of disability and death worldwide, with family support playing a pivotal role in the recovery process. This study aimed to evaluate the…

Date: 2025-12-17

A comparative study of large-vessel and small-vessel primary angiitis of the central nervous system: insights from a Chinese single-center retrospective cohort

Abstract: Primary angiitis of the central nervous system (PACNS) is a rare immune-mediated vasculitis with distinct subtypes (large/medium-vessel [LV-PACNS] and small-vessel…

Date: 2025-12-17

Proteomic insights into mycobacterial responses to elevated riboflavin reveal a role for flavin-sequestering proteins in flavin homeostasis

Abstract: Riboflavin biosynthesis is essential for most microorganisms, yet its production is tightly regulated due to the potential toxic effect of riboflavin and its…

Date: 2025-12-17

Molecular classification and outcomes in pediatric aplastic anemia with myeloid neoplasm-associated gene variants

Abstract: The genetic variations in aplastic anemia (AA) patients are closely related to clonal hematopoiesis, but there is limited research on this topic in children with AA. The…

Date: 2025-12-16

Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL

Abstract: Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm characterized by diverse gene expression profiles and genetic alterations, resulting in…

Date: 2025-12-16

Real-world effectiveness and safety of imeglimin: a single-center retrospective cohort study in Japan

Abstract: This study aimed to evaluate the real-world effectiveness and safety of imeglimin in individuals with type 2 diabetes. We retrospectively reviewed 79 individuals (52…

Date: 2025-12-16

Extracorporeal photopheresis as a therapeutic approach for treatment resistant immune-related adverse events in anti-PD-1-treated melanoma patients

Abstract: Checkpoint inhibition induced immune-related adverse events (irAE) may be steroid-dependent or steroid-refractory and are associated with increased morbidity, mortality…

Date: 2025-12-16

High-altitude immune remodeling in children with Mycoplasma pneumoniae pneumonia: a multi-center transcriptome study

Abstract: A global outbreak of Mycoplasma pneumoniae pneumonia (MPP) emerged following the Corona Virus Disease 2019 (COVID-19) pandemic. Different altitudes significantly impact…

Date: 2025-12-16