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Mental health outcomes and rehabilitation challenges in children with orthopedic trauma: a public health survey from a pediatric rehabilitation center

Abstract: This study aimed to assess mental health outcomes and rehabilitation challenges among Chinese children with orthopedic trauma and to identify multilevel determinants and…

Date: 2025-10-22

Serum IL-17F as a biomarker of infection-independent cirrhosis progression

Abstract: Cirrhosis-associated immune dysfunction (CAID) is characterized by a dysregulated immune response involving both systemic inflammation and immunosuppression, frequently…

Date: 2025-10-22

A comparative analysis of the cholesterol–high-density lipoprotein–glucose index and the triglyceride–glucose index in predicting in-hospital mortality in critically ill ischemic stroke patients

Abstract: The Cholesterol, high-density lipoprotein, and glucose (CHG) index has emerged as a potential indicator of metabolic disturbance, but its prognostic value in patients…

Date: 2025-10-22

Epidemiological trends and future projections of ischemic stroke in children and adolescents: a global analysis from 1990 to 2021

Abstract: Ischemic stroke in children and adolescents is a significant public health concern. This study aims to describe the epidemiological characteristics of ischemic stroke in…

Date: 2025-10-22

Complete cross strain protection against congenital cytomegalovirus infection requires a vaccine encoding key antibody (gB) and T-cell (immediate early 1 protein) viral antigens

Abstract: Cytomegalovirus is a leading cause of congenital disease, and multiple strains enable congenital CMV (cCMV) from both primary and non-primary infections. Therefore, a…

Date: 2025-10-22

Blood-based tumor mutational burden as a biomarker in unresectable non-small cell lung cancer treated with chemoradiotherapy and durvalumab

Abstract: Chemoradiotherapy followed by durvalumab is a potentially curative treatment for unresectable, locally advanced non-small cell lung cancer (NSCLC), but clinical outcomes…

Date: 2025-10-22

Development of a ferroptosis-related signature and identification of NOTCH2 as a novel prognostic biomarker in pancreatic cancer

Abstract: Ferroptosis, a regulated form of iron-dependent cell death, has shown promise as an anti-tumor mechanism. However, its role in pancreatic cancer remains largely…

Date: 2025-10-22

Immunodiagnostic profiling of SPON2 and MSMB as biomarkers in prostate cancer for nanomaterial- based detection strategies

Abstract: This study aimed to validate secreted biomarkers SPON2 and MSMB with tumor-specific expression and immunogenicity for nanomaterial-based prostate cancer diagnostics.…

Date: 2025-10-22

Durvalumab following definitive chemoradiotherapy among patients with stage III NSCLC in the Thai population: a real-world, multicenter observational study

Abstract: In locally advanced non-small cell lung cancer (LA-NSCLC), durvalumab as consolidation therapy following definitive chemoradiotherapy (CRT) was established as the…

Date: 2025-10-22

Identification of immunogenic cell death signature genes in hepatocellular carcinoma: from single-cell transcriptomics to in vitro mechanistic validation and comprehensive prognostic modeling with hundreds of machine learning algorithms

Abstract: Hepatocellular carcinoma (HCC) lacks reliable prognostic biomarkers for immunotherapy. Immunogenic cell death (ICD) represents a promising therapeutic target, but its…

Date: 2025-10-22