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Ameliorative effects and mechanism of Panax notoginseng extract on ulcerative colitis mice based on a multi-omics strategy

Abstract: As a complex and persistent inflammatory bowel disease, the onset and progression of ulcerative colitis (UC) are closely associated with intestinal microbiota dysbiosis,…

Date: 2025-12-15

Anti-LGI1 encephalitis: clinical presentation, imaging features, and prognostic analysis

Abstract: To investigate the clinical features, neuroimaging characteristics, and prognosis of patients with anti–leucine-rich glioma-inactivated 1 (LGI1) antibody associated…

Date: 2025-12-15

Association between monocyte-to-HDL ratio and Fazekas-scaled white matter hyperintensities in migraine patients: a cross-sectional MRI-based study

Abstract: This study aimed to investigate the association between the monocyte-to-high density lipoprotein (HDL) cholesterol ratio (MHR) and the presence and severity of white…

Date: 2025-12-15

Global burden and epidemiological trends of paediatric-onset multiple sclerosis: a cross-sectional analysis of the 2021 global burden of disease study

Abstract: Paediatric-onset Multiple Sclerosis (POMS) is a rare autoimmune disorder of the central nervous system, primarily affecting children and adolescents, characterized by…

Date: 2025-12-15

Ensemble learning prediction model for intraoperative hemodynamic instability in patients with pheochromocytoma

Abstract: Accurately predicting intraoperative hemodynamic instability (HI) in patients with pheochromocytoma is essential for improving prognosis; however, clinically applicable…

Date: 2025-12-12

Assessment of levothyroxine therapy adequacy in low-risk differentiated thyroid carcinoma: a multicenter cohort study

Abstract: This study aimed to evaluate the adequacy of levothyroxine therapy, assessed by serum thyrotropin (TSH) levels, in patients with low-risk differentiated thyroid…

Date: 2025-12-12

Divergent trends of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), syphilis, and gonorrhea in China: a national age-period-cohort analysis, 2006–2020

Abstract: Sexually transmitted diseases (STDs) remain a significant public health challenge globally and in China. This study analyzes incidence trends of three nationally…

Date: 2025-12-12

The effect of pneumovesicoscopic Cohen surgery using a segmented submucosal tunnel and reduced intra-abdominal pressure for the treatment of vesicoureteral reflux in children

Abstract: This study aims to explore the effect of using a segmented submucosal tunnel and reducing intra-abdominal pressure in the treatment of CO 2 leaking from the bladder into…

Date: 2025-12-12

Cetrorelix promotes cell apoptosis via the PI3K–AKT–FOXO1 pathway in epithelial ovarian cancer

Abstract: Epithelial ovarian cancer (EOC) has a dismal prognosis, and recent therapeutic advancements have been limited. The aim of our study was to clarify the role and mechanism…

Date: 2025-12-12

Application of thromboelastogram and coagulation function in evaluating coagulation status of pregnant women across different trimesters

Abstract: Pregnancy induces a hypercoagulable state to prevent hemorrhage during delivery, but it also increases the risk of thrombotic events and postpartum hemorrhage.…

Date: 2025-12-12