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Interpretable machine learning for predicting early neurological deterioration in symptomatic intracranial atherosclerotic stenosis

Abstract: To develop and validate a machine learning (ML) model for early neurological deterioration (END) risk prediction in patients with symptomatic intracranial…

Date: 2025-10-21

Edaravone Dexborneol in acute ischemic stroke patients treated with combined intravenous thrombolysis and mechanical thrombectomy for large vessel occlusion

Abstract: Mechanical thrombectomy (MT), when combined with intravenous thrombolysis (IVT), has emerged as an effective therapeutic strategy for acute ischemic stroke (AIS).…

Date: 2025-10-21

Efficacy and safety of intravenous tenecteplase thrombolysis in diffusion-weighted imaging-negative posterior circulation ischemic stroke

Abstract: Clear evidence supporting thrombolytic therapy in diffusion-weighted imaging (DWI)-negative posterior circulation ischemic stroke (PCIS) is lacking. We aimed to…

Date: 2025-10-21

Colonoscopy outcomes of primary screening negative participants highlight the missed diagnosis problem of colorectal cancer screening: an observational study from Yuexiu district in Guangzhou, China

Abstract: False negatives in colorectal cancer (CRC) screening remained a widespread concern, particularly given the notable incidence of false negative results from fecal…

Date: 2025-10-21

Establishment and comparison of three fear of progression risk prediction models for gynecological malignancies patients based on machine learning

Abstract: This study applied the Society Ecosystems Theory to investigate Fear of Progression (FoP) prevalence and predictors in gynecological malignancy patients. By constructing…

Date: 2025-10-21

Comparison of adverse events between intensity-modulated radiation therapy and tomotherapy for early stage breast cancer: a retrospective cohort study

Abstract: Early stage breast cancer treated with adjuvant radiotherapy with two different techniques, tomotherapy (TOMO) and intensity-modulated radiation therapy (IMRT), and…

Date: 2025-10-21

MFSD12 promotes proliferation, metastasis and invasion of hepatocellular carcinoma cells and its potential correlation with HAVCR2/LGALS9 immune checkpoint axis

Abstract: Major Facilitator Superfamily Domain-containing 12 (MFSD12) has emerged as a critical transmembrane protein with increasingly recognized roles in various cancers. The…

Date: 2025-10-21

Prognostic value of patient-reported outcomes for survival in patients with advanced lung cancer receiving immune checkpoint inhibitors

Abstract: There is potential clinical utility in using patient-reported outcomes (PROs) to predict survival in patients with advanced non-small cell lung cancer. We assessed the…

Date: 2025-10-21

The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8 + CD103 + cDC1 and tissue-resident memory T cell responses

Abstract: Irreversible electroporation (IRE) is a relatively new, non-thermal ablation technology for cancer treatment that requires further investigation to optimize its…

Date: 2025-10-21

Global, regional, and national epidemiology and risk factors of geriatric digestive system cancers from 1990 to 2021

Abstract: Using Global Burden of Disease (GBD) 2021 data, we analyzed incidence, mortality, disability-adjusted life years (DALYs), and risk factors for six geriatric digestive…

Date: 2025-10-21