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Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1

Abstract: Current management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence…

Date: 2025-10-09

Production of functional CD19 CAR T cells under hypoxic manufacturing conditions

Abstract: Chronic lymphocytic leukemia (CLL) has proven difficult to treat with chimeric antigen receptor (CAR) T cell therapy. CLL cells can negatively alter T cell fitness and…

Date: 2025-10-08

The mediating role of social media disorder in the relationship between social media use and self-harm behavior in Indonesian adolescents

Abstract: Social media use in adolescence has been at an all-time high, along with the constant increase of self-harm behavior. Existing research on the relationship between…

Date: 2025-10-08

Predicting the onset of internalizing disorders in early adolescence using deep learning optimized with AI

Abstract: Internalizing disorders (depression, anxiety, somatic symptom disorder) are among the most common mental health conditions that can substantially reduce daily life…

Date: 2025-10-08

Analysis of autonomic nervous function and associated symptoms in patients with peripheral vestibular disorders

Abstract: This study aimed to investigate the differential effects of vestibular lesion sites, specifically the semicircular canals and otolith organs, on autonomic nervous system…

Date: 2025-10-08

A nomogram for predicting individual risk of acute kidney injury after endovascular therapy in large vessel occlusion stroke

Abstract: This study was conducted to develop and validate a nomogram model for the early prediction of acute kidney injury (AKI) in patients with acute ischemic stroke with large…

Date: 2025-10-08

High mesothelin expression is associated with low cytotoxic T cell infiltration in pancreatic cancer

Abstract: Mesothelin (MSLN) is a cell-surface glycoprotein overexpressed in the majority of pancreatic ductal adenocarcinoma (PDAC) cases and represents a promising…

Date: 2025-10-08

Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants

Abstract: Colorectal cancer (CRC) shows significant inter-population heterogeneity in its genomic landscape, yet Middle Eastern populations are underrepresented in large-scale…

Date: 2025-10-08

Comparative short- and long-term outcomes of TOETVA, ETGUA, and COT in thyroid cancer: a propensity score-matched study

Abstract: This study aims to compare the short-term and long-term outcomes of three surgical approaches for thyroid cancer: Transoral Endoscopic Thyroidectomy Vestibular Approach…

Date: 2025-10-08

Diagnostic consistency of GLIM criteria and PG-SGA for malnutrition in patients with pancreatic cancer

Abstract: This study aimed to evaluate the diagnostic consistency between the Global Leadership Initiative on Malnutrition (GLIM) criteria and the Patient-Generated Subjective…

Date: 2025-10-08