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Research Articles Search

Showing 970 of 147,163 result(s)
REDD1 attenuates cholestatic liver fibrosis and suppresses PI3K/AKT/mTOR pathway

Abstract: Liver fibrosis is reversible. Cholestasis is an important factor causing liver fibrosis. However, there are currently no effective anti-fibrotic drugs for cholestatic…

Date: 2025-10-01

Diagnostic efficacy of magnifying endoscopy with blue laser imaging for laryngopharyngeal reflux

Abstract: We aimed to analyze the utility of magnifying endoscopy with blue laser imaging (ME-BLI) in diagnosing laryngopharyngeal reflux (LPR). The study enrolled 106 patients…

Date: 2025-10-01

Nomogram model for prognosis of early colorectal cancer after endoscopic therapy: integration of intestinal microbiota and clinicopathological parameters

Abstract: To integrate the characteristics of intestinal flora and clinical pathological parameters in patients with early colorectal cancer, and to construct and validate a…

Date: 2025-10-01

Identification of shared biomarkers and potential therapeutic targets for antiphospholipid syndrome and recurrent miscarriage by integrated bioinformatics analysis and machine learning

Abstract: Antiphospholipid syndrome (APS) is a group of clinical syndromes of thrombosis or adverse pregnancy outcomes caused by antiphospholipid antibodies that can increase the…

Date: 2025-10-01

The global epidemiology of gastrointestinal cancers attributable to high-BMI: findings from the Global Burden of Disease Study 2021

Abstract: Gastrointestinal (GI) cancers collectively account for over 30% of global cancer-related mortalities. Obesity is a well-established risk factor for GI cancers. We aim to…

Date: 2025-10-01

Efficacy and safety of immune checkpoint inhibitor rechallenge therapy in the treatment of advanced acquired immune-resistant non-small cell lung cancer: a retrospective study

Abstract: Patients with advanced non-small cell lung cancer who have failed first-line immunotherapy and lack driver gene mutations face limited options for subsequent treatment.…

Date: 2025-10-01

A two-transcript classifier model of host genes for discrimination of bacterial from viral infection in ulcerative colitis with opportunistic infections: a discovery and validation study

Abstract: We aimed to develop and validate a classifier model to discriminate bacterial from viral infection in ulcerative colitis with opportunistic infections (UC-OI) by…

Date: 2025-10-01

Burden and trends of major depressive disorders among women of childbearing age and the impact of the COVID-19 pandemic: insights from the global burden of disease study 2021

Abstract: Major depressive disorder (MDD) exhibits a pronounced female predominance, contributing substantially to disability-adjusted life-years (DALYs) among women of…

Date: 2025-10-01

Preliminary study on BRICS sequential therapeutic regimen as salvage treatment for refractory advanced colorectal cancer patients harboring pMMR status

Abstract: Patients with refractory mismatch repair-proficient/microsatellite stable (pMMR/MSS) metastatic colorectal cancer exhibit intrinsic resistance to immune checkpoint…

Date: 2025-10-01

Assessing the impact of enteral nutrition on peripancreatic exudate in acute pancreatitis using CT volume measurement

Abstract: To investigate the effect of enteral nutrition (EN) on peripancreatic exudate in MSAP and SAP patients using CT volume measurement. This retrospective study included 328…

Date: 2025-10-01