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PTPN1 downregulation contributes to pachymic acid-induced mitochondrial apoptosis in colorectal cancer cells

Abstract: Colorectal cancer (CRC) remains a major cause of cancer-related mortality. Pachymic acid (PA), a bioactive triterpenoid derived from Poria cocos, exhibits antitumor…

Date: 2026-10-13

Prevalence and steatosis severity of MASLD in patients with type 2 diabetes mellitus in Kuwait

Abstract: Metabolic dysfunction–associated steatotic liver disease (MASLD) is a common comorbidity in individuals with type 2 diabetes mellitus (T2DM). Given the high prevalence…

Date: 2026-10-13

Comparison between mono-tacrolimus and mono-prednisone in the treatment of ocular myasthenia gravis: a retrospective, observational cohort study

Abstract: The use of tacrolimus (TAC) in ocular myasthenia gravis (OMG) is generally reserved for cases refractory to prednisone (PRED); however, the advantage of monotherapy with…

Date: 2026-10-13

Characteristics of serum Metrnl levels in patients with neuromyelitis optica spectrum disorder and their associations with disease activity and inflammatory biomarkers

Abstract: Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune inflammatory disease for which reliable biomarkers of disease activity are lacking. Meteorin-like…

Date: 2026-10-13

Altered metabolism and endoplasmic reticulum-mitochondria contacts in multiple sclerosis neurons

Abstract: Genetic factors are estimated to account for approximately 30–50% of the risk for developing Multiple sclerosis (MS). Distinct mitochondrial variants, impairments in the…

Date: 2026-10-13

Early differentiation of viral encephalitis and autoimmune encephalitis by clinical and basic laboratory data

Abstract: Timely differentiation between autoimmune and viral causes of encephalitis is critical for guiding disease-specific treatment. This study aimed to develop a scoring…

Date: 2026-10-13

Effect of bacteriophages on cytokine production by human peripheral blood mononuclear cells and their subpopulations

Abstract: Fulfilling a vision that extends beyond their role as antibiotic alternatives, bacteriophages are now recognized as active immunomodulators, a concept aligning with…

Date: 2026-10-13

Preliminary analysis of the proportions and characteristics of dual TCR T cells and dual BCR B cells in echinococcus granulosus-infected mice using scRNA+TCR+BCR-seq

Abstract: Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by Echinococcus granulosus, and the T and B cell responses and regulatory mechanisms in CE remain…

Date: 2026-10-13

Neonatal outcomes and immune reprogramming induced by prenatal opioid and hepatitis C exposure

Abstract: Prenatal opioid exposure (POE) is an escalating public health concern. However, its impact on neonatal immune development remains poorly defined. This study examined how…

Date: 2026-10-13

Modulation of immune and inflammatory responses involving selected galectins and selected immune-inflammatory mediators in women with deep endometriosis coexisting with adenomyosis – preliminary study

Abstract: Endometriosis is characterized by the presence of functionally active endometrial tissue outside the uterine cavity, primarily within the peritoneal cavity. Its etiology…

Date: 2026-10-13