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Predictors of guideline-concordant treatment intensification in metastatic castration-sensitive prostate cancer: an explainable machine learning study

Abstract: Treatment intensification with androgen deprivation therapy (ADT) combined with docetaxel, an androgen receptor pathway inhibitor, or selected triplet regimens is…

Date: 2026-10-13

Fifteen-year real-world pharmacovigilance of multiple sclerosis disease-modifying therapies: adverse event profiles, drug-specific safety signals and clinical implications

Abstract: Disease-modifying therapies (DMTs) are the cornerstone of remission-phase management for multiple sclerosis (MS), a prevalent autoimmune neuroinflammatory disorder of…

Date: 2026-10-13

Peripheral immune-inflammatory markers associated with intracranial progression-free survival after Gamma Knife radiosurgery in patients with non-small cell lung cancer brain metastases: a retrospective cohort study

Abstract: Intracranial outcomes after Gamma Knife radiosurgery (GKRS) for non-small cell lung cancer (NSCLC) brain metastases vary substantially. Peripheral immune-inflammatory…

Date: 2026-10-13

Self-reported practice patterns for cognitive preservation during whole-brain radiotherapy: a multinational cross-sectional survey of radiation oncologists in the Middle East and North Africa

Abstract: Whole-brain radiotherapy (WBRT) remains an important treatment for patients with diffuse brain metastases, but radiation-induced cognitive decline is a major concern.…

Date: 2026-10-13

CNIH4 as a prognostic biomarker and promoter of malignant progression in head and neck squamous cell carcinoma

Abstract: Head and neck squamous cell carcinoma (HNSCC) is a molecularly heterogeneous malignancy with variable clinical outcomes. Although cornichon family AMPA receptor…

Date: 2026-10-13

Survey-based perspectives and reported barriers to DPYD testing among U.S. oncologists

Abstract: Patients with cancer with deleterious DPYD variants are at significantly increased risk for severe toxicity with standard fluoropyrimidine doses. Prior to recent…

Date: 2026-10-13

Efficacy and safety of sacituzumab govitecan in metastatic breast cancer: a single-center retrospective cohort study

Abstract: Metastatic breast cancer (MBC) still remains incurable after advances in the field of systemic therapy. Sacituzumab govitecan (SG) is an antibody-drug conjugate that…

Date: 2026-10-13

Age-related cardiac dysfunction is not associated with shorter telomere length in laboratory rats

Abstract: Ageing is an independent risk factor for cardiovascular disease (CVD). Preclinical models of ageing are needed to better understand human diseases. Telomere shortening…

Date: 2026-10-13

Factors associated with short- and long-term maintenance of sinus rhythm after successful elective electrical cardioversion

Abstract: Electrical cardioversion (ECV) effectively restores sinus rhythm in patients with persistent atrial fibrillation (AF) and atrial flutter (AFL), although arrhythmia…

Date: 2026-10-13

Prospective multicenter study of murmur localization and stage-associated murmur grading in dogs with echocardiographically diagnosed cardiac diseases: the LISTEN study

Abstract: Cardiac auscultation remains fundamental in dogs with suspected cardiac disease, but large prospective datasets describing clinician-recorded murmur localization and…

Date: 2026-10-13