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Machine learning and nomogram for predicting severity of acute cholangitis: development and internal validation of a dual-framework model in a retrospective cohort study

Abstract: Accurate severity grading of acute cholangitis (AC) according to the Tokyo Guidelines 2018 (TG18) is essential for guiding biliary drainage decisions and intensive care…

Date: 2026-10-06

Integrated multi-omics and machine learning identify core mechanobiology-associated immune genes in pulmonary arterial hypertension

Abstract: Pulmonary arterial hypertension (PAH) involves vascular remodeling and altered mechanical signaling. The immune-associated transcriptomic changes accompanying this…

Date: 2026-10-06

Reliability and validity of the Turkish translation of the MOS-HIV health survey in people living with HIV

Abstract: Health-related quality of life (HRQoL) is a key patient-centered outcome in HIV care, particularly in the current treatment era in which virological control is…

Date: 2026-10-06

Cytokine and genetic crosstalk in patients with coexistent familial Mediterranean fever and celiac disease: a cross-sectional study from Türkiye

Abstract: Familial Mediterranean Fever (FMF) and Celiac Disease (CD) are two distinct inflammatory disorders that arise through different immunological pathways, yet they show a…

Date: 2026-10-06

Transcriptomics-guided serum podoplanin and interpretable machine learning for early risk stratification of necrotizing enterocolitis in preterm infants

Abstract: To evaluate podoplanin (PDPN) as a circulating biomarker for early necrotizing enterocolitis (NEC) risk stratification and to determine whether an interpretable…

Date: 2026-10-06

Flow cytometric profiling of water buffalo milk EVs: how lactation stage drives phenotypic evolution and macrophage modulation

Abstract: Milk is more than a traditional nutrient source; it serves as a crucial carrier for milk-derived extracellular vesicles (mEVs), food-derived nanoparticles with diverse…

Date: 2026-10-06

A predictive model based on maternal immune-inflammatory markers for ARDS identification in mechanically ventilated late-preterm and term neonates

Abstract: To develop and internally evaluate a model that uses maternal blood markers obtained before delivery to differentiate neonatal acute respiratory distress syndrome (ARDS)…

Date: 2026-10-06

APASL-ACLF without previous decompensation is immunologically distinct from EASL-CLIF-ACLF with previous decompensation

Abstract: Definitions of acute-on-chronic liver failure (ACLF) differ, with a focus on extrahepatic organ failures on the basis of previously compensated or decompensated…

Date: 2026-10-06

Integrating 72-h BUN/Cr trajectories with interpretable machine learning for 28-day mortality after acute stroke: a dual-center landmark study

Abstract: The blood urea nitrogen-to-creatinine ratio (BUN/Cr) may reflect renal perfusion and systemic stress, but its early course after acute stroke is unclear. We identified…

Date: 2026-10-06

Multimodal neuroimmune diagnostic profiling for pediatric lower urinary tract dysfunction associated with occult sacral nerve abnormalities

Abstract: Persistent pediatric lower urinary tract dysfunction (LUTD) may be associated with occult sacral neural impairment, a clinically challenging condition characterized by…

Date: 2026-10-06