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Disseminated BCG disease and recurrent pulmonary infections in a child with trisomy 21 carrying a novel BACH2 variant of uncertain significance: a 5-year case report

Abstract: Trisomy 21 is associated with combined immune dysregulation, including lymphopenia, impaired responses to vaccines, and heightened susceptibility to respiratory…

Date: 2026-10-05

Serum 25-hydroxyvitamin D, systemic immune-inflammation index, and atherogenic index of plasma in statin-untreated type 2 diabetes: a cross-sectional mediation analysis

Abstract: This cross-sectional study investigated the associations between serum 25-hydroxyvitamin D [25(OH)D] levels, systemic inflammatory burden, and atherogenic lipid profile…

Date: 2026-10-05

Development and internal validation of a CatBoost–SHAP-guided nomogram for significant liver fibrosis in children with chronic hepatitis B

Abstract: Significant liver fibrosis can develop in children with chronic hepatitis B (CHB), yet liver biopsy is invasive and unsuitable for repeated assessment. We developed an…

Date: 2026-10-05

Blood pressure changes after stair climbing in busy and quiet outpatient clinic environments among Tanzanian adults: a randomised crossover study

Abstract: Blood pressure (BP) measured soon after activity may differ from later seated readings. We examined serial BP changes after stair climbing in busy and quiet outpatient…

Date: 2026-10-05

Deep learning-based prediction of HER2 status from breast diffusion-weighted MRI

Abstract: The accurate classification of human epidermal growth factor receptor 2 (HER2) status is very important for the diagnosis and treatment of breast cancer. However, the…

Date: 2026-10-05

Angiographic prevalence of occlusion myocardial infarction and the limited value of serial troponin in patients with non–ST-segment elevation acute coronary syndrome

Abstract: An estimated 25%–34% of patients with non–ST-segment elevation acute coronary syndrome (NSTE-ACS) are diagnosed with an occluded culprit artery during catheterization.…

Date: 2026-10-05

Age-indexed cumulative risk of high myopia estimated from axial length and early axial elongation: a 7-year school-based longitudinal cohort study

Abstract: To develop and validate age-indexed models estimating the cumulative risk of high myopia, defined as axial length (AL)???26.0?mm, using routinely collected ocular…

Date: 2026-10-05

Pulmonary hypertension optimal screening in interstitial lung disease (PHOS-ILD): a scoring system for the detection of pulmonary hypertension in patients with interstitial lung disease

Abstract: Pulmonary hypertension (PH) is a common comorbidity of interstitial lung disease (ILD). Timely detection may improve outcomes through implementation of PH specific…

Date: 2026-10-05

Latent classes and symptom network analysis of kinesiophobia in older adult patients with chronic obstructive pulmonary disease

Abstract: To identify the latent classes of kinesiophobia in older adult patients with chronic obstructive pulmonary disease (COPD), analyze the symptom network structure of…

Date: 2026-10-05

Development and internal validation of machine learning models for identifying suicidal behavior in inpatients with mood disorders

Abstract: Suicidal behavior (SB) is a major concern in mood disorders. Models developed from retrospective records are vulnerable to ambiguous targets, data leakage, and…

Date: 2026-10-05