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The admission neutrophil-to-lymphocyte ratio improves early prediction of poor functional outcome beyond the modified Rankin Scale in viral encephalitis: a cohort study

Abstract: The admission modified Rankin Scale (mRS) strongly predicts outcome in viral encephalitis (VE) but does not capture the systemic inflammatory response of severe disease.…

Date: 2026-10-15

Real-world discrimination and incremental value of first-trimester placental growth factor for hypertensive disorders of pregnancy: a retrospective Chinese cohort

Abstract: Placental growth factor (PlGF) contributes to first-trimester screening algorithms for preeclampsia, but its prognostic performance as an isolated biomarker in routine…

Date: 2026-10-15

Feature-token clinical transformer for 24-h landmark mortality risk stratification in critically ill patients with heart failure: development and multicenter external validation

Abstract: The first 24?h after ICU admission in critically ill patients with heart failure yield heterogeneous EHR evidence across vital signs, laboratory tests, treatments, organ…

Date: 2026-10-15

Multi-environment evaluation and decision-level analysis of clinical prediction models under dataset shift

Abstract: Clinical machine-learning models are often evaluated within a single dataset, although deployment occurs across heterogeneous institutions and measurement processes. We…

Date: 2026-10-15

Higher intraoperative arterial-to-end-tidal carbon dioxide gradients are associated with postoperative respiratory morbidity after lung cancer resection: a retrospective INSPIRE cohort study

Abstract: The arterial-to-end-tidal carbon dioxide gradient may reflect impaired gas exchange during thoracic surgery. We examined its association with postoperative respiratory…

Date: 2026-10-15

Pretransplant plasma soluble PD-1 and recurrence after liver transplantation in ICI-treated hepatocellular carcinoma: an exploratory biomarker study

Abstract: Immune checkpoint inhibitors (ICIs) are increasingly used as bridging or downstaging therapy before liver transplantation (LT) for hepatocellular carcinoma (HCC), but…

Date: 2026-10-15

Psychometric properties of the novel patient-reported Functional Impacts of Narcolepsy Instrument (FINI) using data from phase 3 clinical trials in narcolepsy type 1

Abstract: The Functional Impacts of Narcolepsy Instrument (FINI) is a 28-item patient-reported outcome measure developed to evaluate key functional impacts in people with…

Date: 2026-10-15

Pathogen-mediated selection and phylogeny shape MHC architecture in 33 bat genomes

Abstract: Adaptive immunity is an ancestral hallmark of jawed vertebrates, yet its genomic organisation is far from static—continually reconfigured through extensive gene family…

Date: 2026-10-15

Compound heterozygous RHCE null genotype underlying D?? phenotype in a Chinese pregnant woman: molecular characterization and sequential transfusion strategy

Abstract: The D?? phenotype is an extremely rare Rh blood group variant with absence of C, c, E, and e antigens but preserved D expression, predisposing to anti-Rh17…

Date: 2026-10-15

The impact of comprehensive medical system reform on rural household economic resilience

Abstract: Strengthening the capacity of rural families to withstand health-related economic shocks is critical to consolidating poverty alleviation achievements and preventing…

Date: 2026-10-15