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Cytokine-induced killer cells combined with temozolomide suppress glioblastoma progression in an orthotopic model and demonstrate clinical feasibility in recurrent glioblastoma

Abstract: Glioblastoma (GBM) remains an aggressive primary brain tumor with limited therapeutic options after recurrence. Cytokine-induced killer (CIK) cells are ex vivo-expanded…

Date: 2026-09-30

Fusion-specific co-mutational architecture and treatment-response associations in pediatric core-binding factor acute myeloid leukemia: a multicenter exome-profiled cohort

Abstract: Core-binding factor acute myeloid leukemia (CBF-AML) is defined by one of two founding fusions, but cooperating lesions may differ between fusion subtypes. We…

Date: 2026-09-30

Interpretable machine learning models to predict venous thromboembolism in sepsis patients with type 2 diabetes mellitus

Abstract: Sepsis patients with type 2 diabetes mellitus (T2DM) face a substantially elevated risk of venous thromboembolism (VTE), yet prediction tools tailored for this…

Date: 2026-09-30

Efficacy and safety of air-flow beds for autologous hematopoietic stem cell transplantation in multiple myeloma: a retrospective cohort study

Abstract: Autologous hematopoietic stem cell transplantation (ASCT) is the standard consolidation therapy for multiple myeloma (MM), but its widespread implementation is…

Date: 2026-09-30

Integrated single-cell multi-omics analysis delineates neonatal immune dysregulation associated with gestational diabetes mellitus

Abstract: Gestational diabetes mellitus (GDM) is a common pregnancy complication which could induce immune dysfunction. Although intrauterine hyperglycemia impairs fetal immune…

Date: 2026-09-30

Integrated machine learning and multi-dataset analysis identify SDS as a diagnostic and immune-related hub gene in hepatoblastoma

Abstract: Current clinical diagnostic models lack sufficient sensitivity and specificity for Hepatoblastoma (HB) individualized prediction. This study aimed to identify robust hub…

Date: 2026-09-30

Pathological mechanisms of long non-coding RNA FOXD2-AS1 promoting osteosarcoma mediated by the COI-1/OCN/Runx-2 signaling pathway

Abstract: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Despite three decades of research efforts, no significant improvement in…

Date: 2026-09-30

Integration of bulk and single-cell transcriptomics with spatial analysis identifies candidate hub genes and inferred regulatory programs in atopic dermatitis

Abstract: Atopic dermatitis (AD) is a common chronic inflammatory disorder of the skin. Despite the availability of targeted biologics like dupilumab, heterogeneous treatment…

Date: 2026-09-30

Malignant erythema as a high-specificity cutaneous indicator of malignancy in adult dermatomyositis: a retrospective cohort study

Abstract: Dermatomyositis (DM) is associated with a substantially elevated risk of malignancy, yet the cutaneous features predictive of cancer risk in adults remain insufficiently…

Date: 2026-09-30

Dynamic machine-learning model for early prediction of intraoperative hypotension using 5-minute perioperative time-series data: a multicenter retrospective study

Abstract: Intraoperative hypotension (IOH) is a common and potentially preventable complication strongly associated with postoperative acute kidney injury, myocardial injury, and…

Date: 2026-09-30