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Dupilumab for atopic manifestations in pediatric patients with inborn errors of immunity: efficacy and safety in a genetically diverse cohort

Abstract: Inborn Errors of Immunity (IEI) are monogenic disorders that predispose patients to infections, autoimmunity, atopy, and malignancies. Severe Th2-driven atopic…

Date: 2025-11-21

High-fat diet-induced obesity accelerates puberty in male rats through SMIM20/phoenixin upregulation

Abstract: Controversy exists regarding the relationship between obesity and pubertal onset in boys, and the underlying mechanisms remain unclear. To establish a high-fat diet…

Date: 2025-11-21

Comparison of the systemic inflammatory response index and the systemic immune-inflammatory index in pediatric community–acquired pneumonia caused by respiratory syncytial virus and Mycoplasma pneumoniae

Abstract: This study aims to compare the systemic inflammatory response index (SIRI) and the systemic immune-inflammatory index (SII) in pediatric community–acquired pneumonia…

Date: 2025-11-21

Safety and effectiveness of the Kaiser Permanente early-onset neonatal sepsis calculator in Qatar

Abstract: Early-onset neonatal sepsis is a significant cause of neonatal morbidity and mortality worldwide. Although sepsis rates are declining, neonatal antibiotic use remains…

Date: 2025-11-21

Comparative efficacy and safety of dexmedetomidine and midazolam for conscious sedation in blind nasotracheal intubation: a randomized controlled trial

Abstract: To evaluate the safety and efficacy of dexmedetomidine amnestic analgesia slow induction for blind nasotracheal intubation (BNTI) in oral and maxillofacial surgery.…

Date: 2025-11-21

OXTR rs2254298 polymorphism influences escitalopram response in Generalized Anxiety Disorder: a sex-specific role for oxytocin signaling

Abstract: This study aimed to investigate whether the functional OXTR rs2254298 polymorphism moderates escitalopram response in Generalized Anxiety Disorder (GAD) through oxytocin…

Date: 2025-11-21

The emotion regulation motive of nonsuicidal self-injury mediates the relationship between motor impulsivity and NSSI frequency in adolescents

Abstract: Nonsuicidal self-injury (NSSI) is a common and acute mental health issue among hospitalised adolescents. Although prior research has highlighted the roles of both…

Date: 2025-11-21

Insomnia and depression in Chinese academic researchers: mediation by anxiety and resilience with differences among researchers by educational level

Abstract: Mental health issues such as insomnia may exhibit unique interaction patterns among high-stress populations, with educational attainment potentially playing a…

Date: 2025-11-21

Telemedicine in polish primary care during and after the COVID-19 crisis: a retrospective analysis of over 720,000 consultations

Abstract: The COVID-19 pandemic fundamentally reshaped healthcare delivery worldwide, accelerating the adoption of telemedicine. This study aimed to examine patterns of…

Date: 2025-11-21

Public health implications of delayed diagnosis and treatment of optic neuritis in low-resource settings: a retrospective study of visual recovery outcomes

Abstract: Optic neuritis (ON) is a common cause of visual loss in adults. It is commonly related to or occurs in the scenario of a demyelinating disease. Although treatment leads…

Date: 2025-11-21